Isolated frontal disequilibrium as presenting form of anti‐Hu paraneoplastic encephalomyelitis
Identifieur interne : 002D87 ( Main/Exploration ); précédent : 002D86; suivant : 002D88Isolated frontal disequilibrium as presenting form of anti‐Hu paraneoplastic encephalomyelitis
Auteurs : Yaroslau Compta [Espagne] ; Francesc Valldeoriola [Espagne] ; Xabier Urra [Espagne] ; Beatriz G Mez-Ans N [Espagne] ; Lorena Rami [Espagne] ; Eduardo Tolosa [Espagne] ; Francesc Graus [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-04-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Amygdala (pathology), Autoantibodies (blood), Carcinoma, Small Cell (diagnosis), Carcinoma, Small Cell (immunology), Carcinoma, Small Cell (pathology), Carcinoma, Small Cell (therapy), Combined Modality Therapy, Encephalomyelitis, Follow-Up Studies, Frontal, Gait Apraxia (diagnosis), Gait Apraxia (immunology), Gait Apraxia (pathology), Hu Paraneoplastic Encephalomyelitis Antigens (immunology), Humans, Lung Neoplasms (diagnosis), Lung Neoplasms (immunology), Lung Neoplasms (pathology), Lung Neoplasms (therapy), Lymph Nodes (pathology), Lymphatic Metastasis (pathology), Magnetic Resonance Imaging, Male, Nervous system diseases, Paraneoplastic Syndromes, Nervous System (diagnosis), Paraneoplastic Syndromes, Nervous System (immunology), Paraneoplastic Syndromes, Nervous System (pathology), Paraneoplastic syndrome, Putamen (pathology), anti‐Hu antibodies, frontal disequilibrium, gait failure, paraneoplastic encephalomyelitis.
- MESH :
- chemical , blood : Autoantibodies.
- diagnosis : Carcinoma, Small Cell, Gait Apraxia, Lung Neoplasms, Paraneoplastic Syndromes, Nervous System.
- immunology : Carcinoma, Small Cell, Gait Apraxia, Hu Paraneoplastic Encephalomyelitis Antigens, Lung Neoplasms, Paraneoplastic Syndromes, Nervous System.
- pathology : Amygdala, Carcinoma, Small Cell, Gait Apraxia, Lung Neoplasms, Lymph Nodes, Lymphatic Metastasis, Paraneoplastic Syndromes, Nervous System, Putamen.
- therapy : Carcinoma, Small Cell, Lung Neoplasms.
- Aged, Combined Modality Therapy, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Male.
Abstract
Anti‐Hu encephalomyelitis is one of the most frequent paraneoplastic syndromes, classically presenting with diffuse neurological involvement. We report a 69‐year‐old man presenting with a three‐month isolated, progressive gait disorder with normal neurological examination, except for loss of balance and gait failure reminding frontal disequilibrium, only accompanied by a very mild rigidity of his right foot. MRI of the brain showed hyperintensities in both amygdale and left putamen. EMG study showed no abnormal continuous spontaneous fiber activity. Because of fast progression and MRI findings, anti‐Hu antibodies were tested, resulting positive. Mediastinal biopsy of two adenopathies detected by body‐PET, confirmed an oat‐cell carcinoma. The patient received oral steroids and oncological therapy. One year later, the tumor is in remission. His gait and abnormal posture of right leg are normal. Only mild residual hyperintensities persist on follow‐up MRI. A paraneoplastic syndrome should be considered in the differential diagnosis of subacute, fast progressive gait disorders. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21371
Affiliations:
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paraneoplastic encephalomyelitis</title><author><name sortKey="Compta, Yaroslau" sort="Compta, Yaroslau" uniqKey="Compta Y" first="Yaroslau" last="Compta">Yaroslau Compta</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Institute of Neurosciences, Hospital Clínic i Universitari de Barcelona, Barcelona, Catalonia</wicri:regionArea><wicri:noRegion>Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Institute of Neurosciences, Hospital Clínic i Universitari de Barcelona, Barcelona, Catalonia</wicri:regionArea><wicri:noRegion>Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Urra, Xabier" sort="Urra, Xabier" uniqKey="Urra X" 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Neurology, Institute of Neurosciences, Hospital Clínic i Universitari de Barcelona, Barcelona, Catalonia</wicri:regionArea><wicri:noRegion>Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Institute of Neurosciences, Hospital Clínic i Universitari de Barcelona, Barcelona, Catalonia</wicri:regionArea><wicri:noRegion>Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Graus, Francesc" sort="Graus, Francesc" uniqKey="Graus F" first="Francesc" last="Graus">Francesc Graus</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Institute of Neurosciences, Hospital Clínic i Universitari de Barcelona, Barcelona, Catalonia</wicri:regionArea><wicri:noRegion>Catalonia</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-04-15">2007-04-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="736">736</biblScope><biblScope unit="page" to="738">738</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">35A1CF54D16CC5ED4771083CC98F6EC643FB4198</idno><idno type="DOI">10.1002/mds.21371</idno><idno type="ArticleID">MDS21371</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Amygdala (pathology)</term><term>Autoantibodies (blood)</term><term>Carcinoma, Small Cell (diagnosis)</term><term>Carcinoma, Small Cell (immunology)</term><term>Carcinoma, Small Cell (pathology)</term><term>Carcinoma, Small Cell (therapy)</term><term>Combined Modality Therapy</term><term>Encephalomyelitis</term><term>Follow-Up Studies</term><term>Frontal</term><term>Gait Apraxia (diagnosis)</term><term>Gait Apraxia (immunology)</term><term>Gait Apraxia (pathology)</term><term>Hu Paraneoplastic Encephalomyelitis Antigens (immunology)</term><term>Humans</term><term>Lung Neoplasms (diagnosis)</term><term>Lung Neoplasms (immunology)</term><term>Lung Neoplasms (pathology)</term><term>Lung Neoplasms (therapy)</term><term>Lymph Nodes (pathology)</term><term>Lymphatic Metastasis (pathology)</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Nervous system diseases</term><term>Paraneoplastic Syndromes, Nervous System (diagnosis)</term><term>Paraneoplastic Syndromes, Nervous System (immunology)</term><term>Paraneoplastic Syndromes, Nervous System (pathology)</term><term>Paraneoplastic syndrome</term><term>Putamen (pathology)</term><term>anti‐Hu antibodies</term><term>frontal disequilibrium</term><term>gait failure</term><term>paraneoplastic encephalomyelitis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Autoantibodies</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Carcinoma, Small Cell</term><term>Gait Apraxia</term><term>Lung Neoplasms</term><term>Paraneoplastic Syndromes, Nervous System</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Carcinoma, Small Cell</term><term>Gait Apraxia</term><term>Hu Paraneoplastic Encephalomyelitis Antigens</term><term>Lung Neoplasms</term><term>Paraneoplastic Syndromes, Nervous System</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Amygdala</term><term>Carcinoma, Small Cell</term><term>Gait Apraxia</term><term>Lung Neoplasms</term><term>Lymph Nodes</term><term>Lymphatic Metastasis</term><term>Paraneoplastic Syndromes, Nervous System</term><term>Putamen</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Carcinoma, Small Cell</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Combined Modality Therapy</term><term>Follow-Up Studies</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Encéphalomyélite</term><term>Frontal</term><term>Paranéoplasique syndrome</term><term>Système nerveux pathologie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Anti‐Hu encephalomyelitis is one of the most frequent paraneoplastic syndromes, classically presenting with diffuse neurological involvement. We report a 69‐year‐old man presenting with a three‐month isolated, progressive gait disorder with normal neurological examination, except for loss of balance and gait failure reminding frontal disequilibrium, only accompanied by a very mild rigidity of his right foot. MRI of the brain showed hyperintensities in both amygdale and left putamen. EMG study showed no abnormal continuous spontaneous fiber activity. Because of fast progression and MRI findings, anti‐Hu antibodies were tested, resulting positive. Mediastinal biopsy of two adenopathies detected by body‐PET, confirmed an oat‐cell carcinoma. The patient received oral steroids and oncological therapy. One year later, the tumor is in remission. His gait and abnormal posture of right leg are normal. Only mild residual hyperintensities persist on follow‐up MRI. A paraneoplastic syndrome should be considered in the differential diagnosis of subacute, fast progressive gait disorders. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Espagne</li></country></list><tree><country name="Espagne"><noRegion><name sortKey="Compta, Yaroslau" sort="Compta, Yaroslau" uniqKey="Compta Y" first="Yaroslau" last="Compta">Yaroslau Compta</name></noRegion><name sortKey="G Mez Ns N, Beatriz" sort="G Mez Ns N, Beatriz" uniqKey="G Mez Ns N B" first="Beatriz" last="G Mez-Ans N">Beatriz G Mez-Ans N</name><name sortKey="Graus, Francesc" sort="Graus, Francesc" uniqKey="Graus F" first="Francesc" last="Graus">Francesc Graus</name><name sortKey="Rami, Lorena" sort="Rami, Lorena" uniqKey="Rami L" first="Lorena" last="Rami">Lorena Rami</name><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><name sortKey="Urra, Xabier" sort="Urra, Xabier" uniqKey="Urra X" first="Xabier" last="Urra">Xabier Urra</name><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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